太极拳运动对老年肥胖Ⅱ型糖尿病患者神经肽Y的影响   总被引：9，自引：0，他引：9  

王敬浩  曹阳 《体育与科学》2003,24(4):67-68,72

目的：本文通过对老年肥胖Ⅱ型糖尿病患者血浆神经肽Y水平的对比研究，探讨太极拳运动对老年肥胖Ⅱ型糖尿病患者产生作用的神经内分泌机制。方法：选取老年肥胖Ⅱ型糖尿病患者16人，按自愿原则分为两组，一组为太极拳运动组(10人)，另一组为随意运动组(6人)。各自进行每天1小时，为期3个月的运动锻炼，观察锻炼前及锻炼后空腹、安静状态下的血浆神经肽Y(NPY)水平、血糖和体重指数等指标的变化。结果：太极拳运动组血浆神经肽Y水平下降，其中伴有高甘油三脂血症者6人，NPY水平下降；伴有高胆固醇血症者4人，NPY水平升高。而随意运动组血浆神经肽Y水平变化不显著。结论：太极拳运动对血浆神经肽Y水平的影响，表明了太极拳运动改善老年肥胖Ⅱ型糖尿病患者代谢紊乱的机制与其时机体神经内分泌系统的调节密切相关。  相似文献   

芬兰、德国、中国版糖尿病风险筛查量表的比较及中国版量表的修订     

田杰  任弘  张一民 《北京体育大学学报》2016,39(10):65-70

摘要：目的：1）选择芬兰版糖尿病风险筛查量表、德国版糖尿病风险筛查量表、中国版糖尿病风险筛查量表，对同一批研究对象进行筛查，以评价3个量表在中国糖尿病筛查中的应用效果；2）对中国版糖尿病风险筛查量表进行修订。方法：选取北京某医院参与日常体检者，对其进行问卷调查；由经过培训的调查人员对其进行测量，并记录其年龄、性别、身高、体重、腰围、臀围等形态指标以及空腹血浆葡萄糖和餐后2 h血浆葡萄糖指标。用受试者工作特征曲线（ROC曲线）的曲线下面积（AUC）反应筛查方法的准确度；用约登指数反应不同累计分值对目标人群筛检的效果。结果：1）芬兰版、德国版、中国版量表的AUC分别为0.770（95%CI：0.707~0.826，P<0.0001）、0.658（95%CI：0.589~0.722，P=0.0001）和0.819（95%CI：0.760~0.869，P<0.0001）;2）中国改编版量表的AUC为0.814（95%CI：0.755~0.865，P<0.0001）。结论：1）中国版量表的筛查效果优于芬兰版和德国版量表，较适用于中国人群的糖尿病筛查;2）中国改编版量表包括年龄、BMI、腰围、收缩压、舒张压、体力活动、DM家族史和高血糖史共8个条目（评分范围为0~124分），它具有较好的筛查效果，适用于中国人群的糖尿病筛查。  相似文献   

Induction of diabetes by Streptozotocin in rats   总被引：1，自引：0，他引：1  

A. Akbarzadeh  D. Norouzian  M. R. Mehrabi  Sh. Jamshidi  A. Farhangi  A. Allah Verdi  S. M. A. Mofidian  B. Lame Rad 《Indian journal of clinical biochemistry : IJCB》2007,22(2):60-64

The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats. Intra-venous injection of 60mg/kg dose of Streptozotocin in adult wistar rats, makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes mellitus in the 2–4 days. Induction of experimental diabetes mellitus is indeed the first step in the plan of purification of pancreatic Langerhans islet cells of normal rats for transplanting under the testis subcutaneous of experimentally induced diabetic rats. Streptozotocin induces one type of diabetes which is similar to diabetes mellitus with non-ketosis hyperglycemia in some animal species. For induction of experimental diabetes in male adult rats weighted 250–300 grams (75–90 days), 60mg/kg of Streptozotocin was injected intravenously. Three days after degeneration of beta cells, diabetes was induced in all animals. The diabetic and normal animals were kept in the metabolic cages separately and their body weight, consumption of food and water, urine volume, the levels of serum glucose, insulin and C-peptide quantities in all animals were measured and then these quantities were compared. For a microscopic study of degeneration of Langerhans islet beta cells of diabetic rats, sampling from pancreas tissue of diabetic and normal rats, staining and comparison between them, were done. Induction of diabetes with Streptozotocin decreases Nicotinamide-adenine dinucleotide (NAD) in pancreas islet beta cells and causes histopathological effects in beta cells which probably intermediates induction of diabetes. In this study, we used Streptozotocin for our experiments in induction of experimental diabetes mellitus. After Induction of diabetes, consumption of food and water, volume of urine and glucose increased in the diabetic animals in comparison with normal animals, but the weight of body and the volume of insulin and C-peptide decreased in the diabetic animals. Sampling and staining of pancreas tissue of diabetic and normal rats showed that the Langerhans islet beta cells of diabetic rats have been clearly degenerated. In three days, Streptozotocin makes pancreas swell and at last causes degeneration in Langerhans islet beta cells and induces experimental diabetes. It also changes normal metabolism in diabetic rats in comparison with normal rats. Consumption of water and food, volume of urine, serum glucose increases in diabetic animals in comparison with normal rats but the levels of serum insulin, C-peptide and body weight decreases.  相似文献   

Effect of obesity and insulin resistance on diabetic control     

Kumud Kale  D. K. Rawat 《Indian journal of clinical biochemistry : IJCB》2006,21(1):83-88

Diabetes Mellitus in obese and non-obese Indian individuals.AIMS: Effect of Obesity and insulin resistance on diabetic control.SETTINGS AND DESIGN: 50 each groups Diabetic individuals obese and non-obese.METHODS AND MATERIAL: On selected 50 each group diabetic patient and normal, following blood investigations has been performed—Plasma Glucose, Glycohemoglobin and Serum Insulin.STATISTICAL ANALYSIS USED: Individuals patient’s results were analyzed and compared with the normal controls.RESULTS AND CONCLUSION: The changes in glycosylated haemoglobin are mainly proportional to the post lunch glucose level (r=0.773) (p<0.01) and not correlated to circulating insulin or the body mass index. However the levels were higher in obese diabetes (Type I and II both) than in non-obese. Mechanism of resistance in insulin receptor interactions due to obesity is well known. However, obesity does not seem to affect directly glycosylated haemoglobin. Under such circumstances, the reduction of weight for a diabetic person can improve sugar control by minimizing insulin resistance and thereby can improve glycosylated haemoglobin levels.  相似文献   

Effect of fangchinoline on oxidant status in male albino rats with streptozotocin-induced diabetes     

《Electronic Journal of Biotechnology》2021

BackgroundDiabetes is a metabolic disorder caused by defects in insulin production and activity. During disease progression, changes in lipid peroxidation cause structural modifications via production of free radicals. Fangchinoline is a well-known alkaloid present in Stephaniae tetrandrine S. Moore, which has demonstrated antioxidant, anticancer, and anti-inflammatory activities.ResultsThe present study analyzed the anti-diabetic and antioxidant effects of fangchinoline in male rats with streptozotocin-induced diabetes. Rats were divided into the following groups: normal control, diabetic, diabetic + fangchinoline 100 mg/kg, diabetic + fangchinoline 200 mg/kg and diabetic + glibenclamide 600 µg/kg. The treatment was administered orally for 45 consecutive days. Lipid peroxidation was substantially increased by >50% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. However, fangchinoline supplementation significantly reduced lipid peroxidation to near normal levels. Reactive oxygen species levels were substantially increased by >500% in the serum, as well as the liver, kidney, and heart tissues of diabetic rats. Fangchinoline supplementation reduced reactive oxygen species to near normal levels. Fangchinoline supplementation significantly improved superoxide dismutase, glutathione peroxidase, catalase, and reduced glutathione levels in diabetic rats. Total hexoses, sialic acid, hexosamines, and fucose were increased in diabetic rats, whereas fangchinoline supplementation significantly reduced these total hexoses, sialic acid, hexosamines, and fucose to near normal levelsConclusionsSupplementation with fangchinoline led to significant attenuation of the levels of lipid peroxidation, ROS, and glycoprotein components such as total hexoses, hexosamines, sialic acid, and fucose, while improving antioxidant marker levels.How to cite: Xia J, Huang W, Zhou F. Effect of fangchinoline on oxidant status in male albino rats with streptozotocin-induced diabetes. Electron J Biotechnol 2021;53. https://doi.org/10.1016/j.ejbt.2021.07.005  相似文献   

Exercise but not metformin improves health-related quality of life and mood states in older adults with type 2 diabetes     

Liliana C. Baptista  Aristides M. Machado-Rodrigues  Raul A. Martins 《European Journal of Sport Science》2017,17(6):794-804

The aim of this cohort study is to analyse the effect of three types of treatment: (i) exercise training with multicomponent exercise (E); (ii) pharmacologic treatment with oral hypoglycaemic drug – metformin (M); and (iii) a combined therapy – exercise and metformin (E?+?M) on health-related quality of life (HRQoL) and mood states in older adults with type 2 diabetes (T2D) with comorbidity in an early stage of the disease. Participants (n?=?284) underwent 1 of the following 3 conditions: (i) E (n?=?59) trained three times/week; (ii) M (n?=?30) used 850?mg of metformin twice daily; and (iii) E?+?M (n?=?195) combined exercise and metformin. Furthermore, participants completed baseline and 2-year follow-up evaluations including a Shortform Health Survey 36, Profile of Mood States – Short-form, the health history questionnaires, anthropometric, and blood biochemistry. E and E?+?M revealed improved mood states, with large effect size on the vigour domain, and moderate effect size in the anger and total mood disturbance (TMD) domains (P?<?0.05), in comparison with the M group. After 24 months’ intervention, the E and E?+?M groups perceived better physical and mental HRQoL than the M group. The M group unchanged HRQoL domains (P?>?0.05). Metformin had no significant effect on the self-referred HRQoL in T2D participants aged above 60 years, in an early stage of the disease. The E and E?+?M were the most effective long-term therapies to improve mood states and HRQoL in older adults with T2D.  相似文献   

太极拳运动对2型糖尿病患者血脂成分及胰岛素抵抗的影响   总被引：2，自引：0，他引：2  

蒋荣康 《搏击·武术科学》2007,4(10):35-36

为了进一步揭示太极拳锻炼对2型糖尿病影响的机制,文章以16名中老年肥胖者为对象,观察了太极拳锻炼前后血脂成分和胰岛素敏感性等指标的变化,经过20周太极拳运动后,患者血清TG、LDL-C、GHbA1c、FPG等成分明显降低,HDL-C水平则明显升高(p<0.01),ISI明显下降,说明太极拳运动可以改善2型糖尿病患者血脂成分,有助于胰岛素抵抗功能的改善。  相似文献   

有氧运动对糖尿病大鼠血糖等生化指标的影响     

龚云 《四川体育科学》2009,(3):31-33

观察有氧运动对糖尿病模型大鼠血糖等生化指标的影响。四氧嘧啶诱导的糖尿病大鼠20只,随机分为实验组（10只）和对照组（10只）。实验组动物进行45d连续跑台运动,第46d断头取血测血糖、转氨酶、尿素氮和血常规指标。结果发现：有氧运动对糖尿病大鼠的BUN、MCV、MCH、MCHC无显著性（p〉0.05）影响;但与对照组相比,血糖、GPT、RBC、HCT、HGB、RDW、PLT、WBC却发生了显著性（p〈0.05）变化。  相似文献   

Association of Aberrations in One Carbon Metabolism with Intimal Medial Thickening in Patients with Type 2 Diabetes Mellitus     

R. Dhananjayan  T. Malati  Y. Rupasree  Vijay Kumar Kutala 《Indian journal of clinical biochemistry : IJCB》2015,30(3):263-270

The present work was aimed to study the association of one carbon genetic variants, hyperhomocysteinemia and oxidative stress markers, i.e., serum nitrite, plasma malondialdehyde (MDA) and glutathione (GSH) on intimal medial thickening (IMT) in patients with type 2 diabetes mellitus (T2D). A total number of 76 subjects from ACS Medical College and Hospital, Chennai, India were included in the study, i.e., Group I (n = 42) of T2D and Group II (n = 34) of age- and sex matched healthy controls. The glycated haemoglobin was measured by ion-exchange resin method; plasma homocysteine by Enzyme Linked Immunosorbant Assay method; serum nitrite (nitric oxide, NO), plasma MDA and GSH by spectrophotometric methods; the IMT by high frequency ultrasound. The polymorphisms of one carbon genetic variants were genotyped using polymerase chain reaction-restriction fragment length polymorphism and amplified fragment length polymorphism methods. Results indicate that methyltetrahydrofolate homocysteine methyl transferase (MTR) A2756G allele was found to be protective in T2D and the other variants were not significantly associated with T2D. Glutamate carboxypeptidase II (GCP II) C1561T (r = 0.34; p = 0.05) and methylene tetrahydrofolate reductase (MTHFR) C677T (r = 0.35; 0.04) showed positive correlation with plasma homocysteine in T2D cases. In this study, MTR A2756G allele was found to be protective in T2D; GCP II C1561T and MTHFR C677T showed positive association with plasma homocysteine in T2D cases. Among all the genetic variants, MTR A2756G was found influence IMT. RFC 1 G80A and TYMS 5′-UTR 2R3R showed synergistically interact with MTR A2756G in influencing increase in IMT.  相似文献   

VDR,RXR, Coronin-1 and Interferonγ Levels in PBMCs of Type-2 Diabetes Patients: Molecular Link between Diabetes and Tuberculosis     

Kirtimaan Syal  Anand Srinivasan  Dibyajyoti Banerjee 《Indian journal of clinical biochemistry : IJCB》2015,30(3):323-328

Diabetes and tuberculosis are world’s most deadly epidemics. People suffering from diabetes are susceptible to tuberculosis. Molecular link between the two is largely unknown. It is known that Vitamin A receptor (RXR) heterodimerizes with Vitamin D receptor (VDR) and Peroxisome proliferator-activator receptor-γ (PPARγ) to regulate Tryptophan-aspartate containing coat protein (TACO) expression and fatty acid metabolism respectively, so it would be interesting to check the expression of these genes in diabetes mellitus (DM) patients which might explain the susceptibility of diabetics to tuberculosis. In this study, we checked the expression of RXR, VDR, TACO and Interferon-γ (IFNγ) genes in type-2 DM patients for understanding the link between the two diseases. We observed down regulation of RXR gene and corresponding up regulation of TACO gene expression. We have not observed significant change in expression of VDR and IFNγ genes in type-2 DM patients. Repression of RXR gene could hamper VDR-RXR heterodimer formation and thus would up regulate TACO gene expression which may predispose the type-2 DM patients to tuberculosis. Also, decrease in RXR-PPARγ heterodimer could be involved in DM.  相似文献